De grootste kennisbank van het HBO

Inspiratie op jouw vakgebied

Vrij toegankelijk

Terug naar zoekresultatenDeel deze publicatie

Neural Guidance Conduits in Peripheral Nerve Repair

a Contemporary Alternative to Autografts

Open access

Rechten:Alle rechten voorbehouden

Neural Guidance Conduits in Peripheral Nerve Repair

a Contemporary Alternative to Autografts

Open access

Rechten:Alle rechten voorbehouden

Samenvatting

Peripheral nerve injuries (PNIs) are both prevalent throughout society and challenging to treat, especially when the injury is large
(> 5mm). When treated unsuccessfully, PNIs often result in significantly diminished quality of life, providing strong motivation for finding reliable treatment procedures. Currently, the preferred method of treatment (autografts) struggles to bridge larger severed nerves gap and is associated with numerous limitations, such as immunological rejection.
In this review, we explore an alternative approach that makes use of neural guidance conduits (NGCs), which emulate the natural environment of developing peripheral nerves and serve as a supportive structure for regeneration. As peripheral nerve cells interact strongly with their immediate surroundings (i.e., their extracellular matrix (ECM)) throughout growth, providing such a support can, in principle, enable directionally selective nerve regrowth. Specifically, we review the growth and regeneration of the PNS and contextualize how different ECM moleculesinfluence nerve growth in the PNS. Select NGC designs are discussed, with emphasis placed on how design criteria affect the regenerative process. Though they have not yet become the de facto treatment
approach for PNI treatment, the elegance and flexibility offered by NGCs suggest that they will play a crucial role in tissue-engineering-based repairs in the near future.

Toon meer
OrganisatieHAN University of Applied Sciences
AfdelingAcademie Toegepaste Biowetenschappen en Chemie
PartnerLife Sciences Research Institute, Halifax Canada
Datum2024-02-09
TypeBachelor
TaalEngels

Op de HBO Kennisbank vind je publicaties van 26 hogescholen

De grootste kennisbank van het HBO

Inspiratie op jouw vakgebied

Vrij toegankelijk