Samenvatting

Autism Spectrum Disorder (ASD) is a neurobiological condition affecting about 1% of the population, characterized by repetitive behaviors, restricted interests, and communication deficiencies. While ASD has both genetic and environmental influences, the role heritable yet non genetic gastrointestinal microbiome is of great importance to this review. Research indicates differences in the gut microbiome of individuals with ASD, with increased Pseudomonadota and Firmicutes and decreased Bacteroidetes. ASD patients often experience gastrointestinal (GI) issues, but these are frequently overlooked. With the gut-brain axis being wide accepted in the scientific field it is of great importance to look more into the effect of the gut microbiome on ASD symptoms. Two treatment method are review, first supplementing 5-aminovaleric acid (5AV) and taurine and second supplementing L. reuteri. Both methodsresult in an increase in the social behaviors and thus hold great promise.