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Transcription and DNA damage dynamics in the dopaminergic system following low dose ionizing radiation.

Rechten: Alle rechten voorbehouden

Transcription and DNA damage dynamics in the dopaminergic system following low dose ionizing radiation.

Rechten: Alle rechten voorbehouden

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Abstract

During Parkinsons Disease, post-mitotic dopaminergic neurons degenerate after aging. The loss of dopaminergic neurons cause severe motor dysfunction, resting tremors, slow movement, rigidity and postural instability. Post-mitotic dopaminergic neurons do not tend to proliferate, however earlier studies showed that dopaminergic do repair damaged DNA. The precise mechanism of repair and its dynamics are still unclear. In this study we try to make clear what reactions Low Doses of Ionizing Radiation (LDIR) trigger in normal functioning mice. In this research we show that after induction of DNA damage by LDIR triggers MAPK responses which counteract the stress symptoms in the DA neurons. After time DA neurons return back in homeostasis. The findings in this research pave the way for further studies on the dopaminergic system, with for instance mice that elicit PD symptoms.

OrganisatieAvans Hogeschool
OpleidingBiologie en Medisch Laboratoriumonderzoek-Breda
AfdelingATGM Academie voor de technologie van Gezondheid en Milieu
Jaar2015
TypeBachelor
TaalEngels

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